His areas of research are poetics, reception aesthetics and digital philology. Currently, he is carrying out the ICON-funded project Observatory on Dante Studies, where he focuses on the reception of Dante's work - and its translations - in the Netherlands. 
He has widely published on translation, mainly on the topic of poet-translators (including Wordsworth, Montale, Penna), is the author of Michelangelo in Parnaso. La ricezione delle «Rime» tra gli scrittori (Marsilio 2019), and editor of Esercizi di poesia. Saggi sulla traduzione d’autore (Istituto Italiano di Cultura 2017). 

He is a member of the editorial board of «Testo a fronte», one of the leading journals dedicated to the theory and the practice of translation.

For his scholarly work, dr. Cascio has been awarded the Elsa Morante prize, the international Proserpina prize and the G.A. Borgese prize.